Breast cancerOvarian cancerLung cancerGastric cancer Liver cancerPan-cancer Breast cancerLiver cancerPan-cancer Breast cancer Custom Pan-cancer DNA

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Compute median over entire dataset:
Backward reference:

Affy id/ Gene symbol:

Use multiple genes Use multiple genes Use list of genes Use mean expression of selected genes Use ratio of two genes Filter by median expression more genes param Example Example input for multiple genes: 1007_s_at 1 200000_s_at -1 31637_s_at 0.5 40016_g_at -2 Explanation: first: normal, second: gene is inverted, third: gene has weight, fourth: gene has weight and is inverted You can also use following format: 1007_s_at, 1 200000_s_at, -1 31637_s_at, 0.5 40016_g_at, -2

Variant type:

all mutations disruptive mutations coding mutations

Survival:	Overall survival (n=5997)Relapse free survival (n=3722)
Follow up threshold:	all2 months4 months6 months12 months18 months24 months30 months36 months48 months60 months120 months180 months240 months		Censore at threshold:

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	Select all (n=7874)
	Bladder Carcinoma (n=408)
	Breast cancer (n=980)
	Cervical squamous cell carcinoma (n=286)
	Colon adenocarcinoma (n=394)
	Cutaneous melanoma (n=465)
	Esophageal Squamous Cell Carcinoma (n=0)
	Head-neck squamous cell carcinoma (n=494)
	Kidney renal clear cell carcinoma (n=332)
	Kidney renal papillary cell carcinoma (n=278)
	Liver hepatocellular carcinoma (n=358)
	Low grade glioma (n=501)
	Lung adenocarcinoma (n=508)
	Lung squamous cell carcinoma (n=488)
	Ovarian cancer (n=272)
	Prostate adenocarcinoma (n=492)
	Sarcoma (n=235)
	Stomach adenocarcinoma (n=372)
	Thyroid carcinoma (n=485)
	Uterine corpus endometrial carcinoma (n=526)

Restrict analysis to subtypes...

Stage:	all 1 (n=1549) 2 (n=1336) 3 (n=1051) 4 (n=593)
Gender:	all female (n=3619) male (n=2403)
Race:	all white (n=4337) asian (n=471) black/african american (n=643)
Grade:	all 1 (n=247) 2 (n=1028) 3 (n=1219) 4 (n=56)
Mutation burden:	all high (n=3049) low (n=2973)

Restrict analysis based on cellular content…

Basophils:	all enriched (n=2746) decreased (n=2903)
B-cells:	all enriched (n=3114) decreased (n=2535)
CD4+ memory T-cells:	all enriched (n=3111) decreased (n=2538)
CD8+ T-cells:	all enriched (n=2809) decreased (n=2840)
Eosinophils:	all enriched (n=2437) decreased (n=3212)
Macrophages:	all enriched (n=3337) decreased (n=2312)
Mesenchymal stem cells:	all enriched (n=2763) decreased (n=2886)
Natural killer T-cells:	all enriched (n=2423) decreased (n=3226)
Regulatory T-cells:	all enriched (n=2854) decreased (n=2795)
Type 1 T-helper cells:	all enriched (n=2791) decreased (n=2858)
Type 2 T-helper cells:	all enriched (n=3331) decreased (n=2318)

Please note: the generated p value does not include correction for multiple hypothesis testing by default.

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n = number of patients with available clinical data

Manuscript in submission. In the meantime, please kindly cite our paper to support further development: Nagy A, Munkacsy G, Gyorffy B: Pancancer survival analysis of cancer hallmark genes, Sci Rep. 2021 Mar 15;11(1):6047.