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AMLBreast cancerColon cancerGastric cancerLung cancerMyelomaOvarian cancerPancreatic cancer
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Breast cancerLiver cancerPan-cancer
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Breast cancerLiver cancerPan-cancer
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Breast cancer
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Custom
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Pan-cancer DNA
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Immunotherapy

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1. Select gene symbol/Uniprot ID:

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2. Select dataset:

Liu_2014 (n=126)

TCGA-RPPA (n=873)

DeMarchi_2015 (n=112)

Tang_2018 (n=118)

Survival options

Survival	OS (n=1064)RFS (n=986)DMFS (n=126)
Split patients by	--none--lower quartilelower tertilemedianupper tertileupper quartile
	Auto select best cutoff
	Trichotomization : --none--T1 vs T3Q1 vs Q4

Follow up threshold:

all2 months4 months6 months12 months18 months24 months30 months36 months48 months60 months120 months180 months240 months

Censore at threshold:
Compute median survival:
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Exclude samples with a protein expression of 0:

Restrict analysis to subtypes...

ER status: (n=1126)	all each separately positive (n=771) negative (n=355)
PGR status: (n=946)	all each separately positive (n=532) negative (n=414)
HER2 status: (n=704)	all each separately positive (n=133) negative (n=571)

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Stage: (n=923)	all each separately 1 (n=134) 2 (n=551) 3 (n=220) 4 (n=18)
Grade: (n=160)	all each separately 1 (n=10) 2 (n=35) 3 (n=115)
Lymph node status: (n=1153)	all each separately positive (n=522) negative (n=631)

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T: (n=984)	all each separately 1 (n=233) 2 (n=593) 3 (n=122) 4 (n=36)
N: (n=859)	all each separately no reg.ln.met. (n=407) reg.ln.met. (n=287) tumor spread between N1 and N3 (n=103) tumour spread to distant or numerous reg. ln. (n=62)
M: (n=757)	all each separately no metastasis (n=737) metastasis (n=20)

Restrict analysis to selected cohorts...

Race: (n=930)	all each separately white (n=682) asian (n=58) black/african american (n=190)
Menopausal status: (n=125)	all each separately pre (n=59) post (n=66)

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Radiation therapy: (n=122)	all 0 (n=69) 1 (n=53)
Hormone therapy: (n=1111)	all each separately any (n=1111) Tamoxifen (n=315) Anastrozole (n=60)
Chemotherapy: (n=999)	all each separately any (n=999) Doxorubicin (n=307) 5-FU (n=84) Docetaxel (n=150) Cyclophosphamide (n=410) Paclitaxel (n=188) Carboplatin (n=23)

Compare datasets

METABRIC: long follow-up (median: 94 months), average characteristics (78% ER positive, 12% HER2 positive), treatment data available for this dataset only!
TCGA: very short follow-up (median only 25 months), no grade.
GSE40267: almost exclusively ER negative patients (92%).
GSE19783: nodal status not available, 38% ER negative, high proportion of HER2 positive patients (18%).

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Please note: the generated p value does not include correction for multiple hypothesis testing by default.

Please kindly cite our latest paper to support further development: Győrffy B. Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer, Computational and Structural Biotechnology Journal, 2021;19:4101-4109, https://doi.org/10.1016/j.csbj.2021.07.014